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Seek immediate medical attention for the following warning signs: Severe abdominal pain , particularly if persistent or radiating to the back, which may indicate pancreatitis (a rare but serious adverse effect) Persistent vomiting that prevents adequate fluid intake Signs of dehydration including decreased urination, dark urine, dizziness, dry mouth, or confusion Hypoglycemia symptoms such as shakiness, sweating, rapid heartbeat, hunger, confusion, or irritability (especially in patients taking insulin or sulfonylureas) Symptoms of gallbladder disease such as right upper abdominal pain, fever, or jaundice (yellowing of skin or eyes) Severe constipation or inability to pass stool or gas, accompanied by abdominal distention Signs of allergic reaction including rash, swelling of face/tongue/throat, or difficulty breathing (call 911) Patients with type 2 diabetes should monitor blood glucose levels more frequently during periods of significant nausea or vomiting, as reduced food intake can affect glycemic control

L-Carnitine is a conditionally essential nutrient involved in the transport of long-chain fatty acids into mitochondria, where fatty acids can be oxidized for energy

3.2 SPY001, SPY002, SPY003 A clinical trial investigating SPY001 SPY002, and SPY003 (long-acting IgG1 antibodies targeting 47, TL1A, and IL-23 respectively) both as monotherapies and in combinations for moderate to severe UC is currently undergoing

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