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Weight of evidence: Overall evidence is Low-Moderate: multiple animal studies and a growing number of small clinical trials suggest benefits across gutbrain signaling, social and behavioral domains, gastrointestinal symptoms, and neurophysiological patterns, yet most human studies rely on caregiver-reported outcomes, lack biomarker integration, and seldom control for diet, comorbidities, or baseline microbiome composition

This means that people who are at risk for one condition are often at risk for the other

SASP, senescence-associated secretory phenotype

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The diagrams and MRI images demonstrate a normal spinal canal in the lumbar spine