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Additionally, treatment with IDV or NFV was shown to cause increased mitochondrial ROS production and premature senescence in skin fibroblasts (Manda et al., 2011)

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Further, these researchers showed higher XOR redox, the ratio of XO to total XOR, in the plasma of advanced CKD patients, indicating its role in elevated ROS production.Nitric oxide (NO) influences kidney function and aids in maintaining normal blood pressure by promoting natriuresis and diuresis, aiding in adaptation to variations in dietary salt intake