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GLP-1s are the most successful, clinically-backed tools for diabetes and weight management on the planet, but side effects like nausea, diarrhea, constipation, fatigue, muscle loss are getting in the way

The assay was performed according to the manufacturers protocol

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In db/db mice, CK treatment increases secondary BAs, such as lithocholic acid (LCA) and deoxycholic acid (DCA) through changes in the gut microbiota, especially the Ruminococcaceae family, and up-regulation of cytochrome P450 family 7 subfamily B member 1 ( Cyp7b1 ) and cytochrome P450 family 27 subfamily A member 1 ( Cyp27a1 ) and down-regulation of cytochrome P450 family 8 subfamily B member 1 ( Cyp8b1 ), which changes BA biosynthesis from the classical pathway to the alternative pathway

article/abs/pii/S0146280624000422 Drucker, D