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Melanotan 2 works by stimulating the melanocortin receptors in the body, which in turn can increase melanin production

Histology showed a compact stratum corneum, irregular epidermal acanthosis, and increased pigmentation in the basal layer

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The other 20% is related to enzymatic non-erythroid sources (11, 12)

Sirtuin 1 (SIRT1) SIRT1 is an enzyme located primarily in the cell nucleus that deacetylates transcription factors to regulate cellular processes including longevity and stress response