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M., Dewhirst, M

3 Human -cell lipotoxicity in vitro It is well documented that, upon acute exposure, LC-FFA can promote insulin release from human islets in vitro (55, 56), whilst chronic exposure impairs insulin secretion (5456) and activates apoptosis (5760)

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kdr caused by point mutations of the target site, with the substitution of leucine (L) by phenylalanine (F), histidine (H) or serine (S) in Vssc in IIS6 at codon 1014, has been reported in mosquitoes of genera Anopheles and Culex [59]