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Beta Blockers Although the results of a clinical study did not indicate a safety problem associated with the administration of dihydroergotamine mesylate nasal spray to subjects already receiving propranolol, there have been reports that propranolol may potentiate the vasoconstrictive action of ergotamine by blocking the vasodilating property of epinephrine

It is important to note that patients with a history of major depression were actually excluded from the phase 3 randomized controlled trials (RCTs) of these medications 10,11,12,13,14,15,21,22,23

Fainting, anxiety, nausea, or loss of consciousness during the procedure

Another issue is the fact that the study did not have a designated follow-up period to measure the rate of relapse

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