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And c-di-GMP is another ubiquitous second messenger with potent immunomodulatory properties in biofilm, stimulating innate immunity and regulating biofilm formation, planktonic motility, and virulence

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Igarashi T, Huang TT, Noble LJ (2001) Regional vulnerability after traumatic brain injury: gender differences in mice that overexpress human copper, zinc superoxide dismutase

Biceps tendon ruptures can occur due to acute injuries alone or may be due to an acute-on-chronic injury, meaning that the tendon has already experienced some level of pre-existing disease or degeneration, called tendinosis