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[PMC free article] [PubMed] [Google Scholar] 184.Cruz M.E.M., Corvo M.L., Martins M.B., Simes S., Gaspar M.M

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The discovery that gut microbial metabolism of L -carnitine involves a second quantitatively significant sequential pathway for TMA formation from distinct microbial taxa suggests numerous targets are at hand if one wishes to pharmacologically manipulate the catabolism of carnitine into TMA/TMAO for potential treatment or prevention of CVD, such as through shifting of gut bacterial composition (probiotic, prebiotic) or inhibition of bacterial enzymatic activities