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Some larger compounding facilities (called 503B outsourcing facilities) register with the FDA and follow stricter manufacturing standards, but they still don't submit the extensive clinical trial data required for approval

Patients with normal kidney function have an incidence of hyperkalemia of about 2% when they take these drugs, but those with underlying chronic kidney disease or other circumstances (e.g., higher baseline potassium level, diuretic use, diabetes) can be at much greater risk

Food and Drug Administration granted approval to Wegovy (semaglutide) in 2021