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In septic mice, semaglutide attenuated sickness behavior, hypothermia, systemic inflammation, and lung injury through the downregulation of pro-inflammatory cytokines (TNF- , IL-1, IL-6, CXCL1), suppression of neutrophil infiltration, and decreased expression of genes associated with tissue remodeling and inflammation (Mmp9, Timp1, Ly6g)

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The pattern suggests that each additional receptor target provides incremental but meaningful improvements

Tirzepatide is an approved GLP-1R/GIP dual agonist developed by Eli Lilly, garnering significant attention alongside SEMA in the field of T2DM and weight loss

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