* Sweating * Headache * Dizziness **Very Rare Side Effects (may affect up to 1 in 10,000 people):** * Acne **Not Known (frequency cannot be estimated from the available data):** * Nerve damage (neuropathy) with prolonged use
High oral bioavailability Caco-2 cell assays showed excellent passive and active membrane transport with no detectable efflux (Neelakantan et al., 2018)
Faster tendon healing in animal models Journal of Applied Physiology, 2011 Knee pain relief in human patients Journal of Orthopaedic Surgery and Research, 2021 Safety profile across soft tissue indications Current Pharmaceutical Design, 2019 The statements on this page have not been evaluated by the Food and Drug Administration
Certain medical conditions and medications increase B12 requirements: Long-term use of metformin (diabetes medication) or proton pump inhibitors (PPIs for acid reflux) can impair B12 absorption [13] [14] Gastrointestinal conditions such as Crohn's disease, coeliac disease, or previous gastric surgery Autoimmune conditions beyond pernicious anaemia may affect B12 metabolism When to contact your GP : If you are taking B12 supplements or receiving injections but continue to experience symptoms, request a review
These cases show that both placebo and real biologic responses are part of the picture
