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Yasmin Kamal , Alessandra Tessitore, Weidong Zhou, Mark Ross, Lance A

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Targeting lymph nodes for enhanced cancer vaccination: From nanotechnology to tissue engineering

10.1007/s11096-012-9615-5 259 WangY.-W.JouC.-H.HungC.-C.YangM.-C

Neurological Relevance Preclinical evidence suggests broader neuroprotective potential: In traumatic brain injury models, SS-31 reduced mitochondrial swelling, neuronal loss, and neuroinflammation Aged mice treated with SS-31 showed significantly improved exercise tolerance, muscle strength, and mitochondrial efficiency Studies demonstrate protection against ischemic injury and enhanced cardiac output Phase 3 trials are ongoing for dry age-related macular degeneration and primary mitochondrial myopathy (Stealth BioTherapeutics pipeline) Implications for Brain Aging Mitochondrial dysfunction is a hallmark of brain aging and neurodegeneration