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Harlan's research highlights a crucial breakthrough: "By the late 1970s, physicians at Mayo Clinic thoroughly understood how to prevent, treat, and avoid TSW and continued to use low potency topical steroids on the face for chronic recurring dermatitis." [12] This understanding would eventually lead to the development of safer formulations that could manage perioral dermatitis without triggering the dependency cycle

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However, BPA binding to zebrafish GPER is inhibitory 21 , which could have caused the reductions in p-ERK and p-Akt identified in retinal homogenates in response to low BPA exposure