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demonstrated the cystine residue C466 on the Src family kinase Lyn as being the direct target of H 2 O 2 to induce neutrophil recruitment to the wound site, mediated through ERK signalling 16

This not only drastically reduces the amount of ATP available for physical and cognitive tasks but also physically destabilizes the nervous system, leading to profound fatigue and neurological impairment

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Disease severity also depends on the specific target of these IgG [170, 171, 178, 179]