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In Theta, Sigma and Beta members, the interaction surface is rather hydrophilic whereas in Alpha, Phi, Mu, Omega, Pi, Tau, Zeta, and FuA GSTs, the surface is more hydrophobic (Frova, 2006)
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The needle penetrates into the reticular dermis, causing excessive bleeding, prolonged redness lasting 5 to 7 days instead of 1 to 2, and increased risk of post-inflammatory hyperpigmentation