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Neurology 12, 761912

The two main signaling cascades started by IGF1 LR3 receptor binding are the phosphatidylinositol 3-kinase (PI3K)/Akt pathway and the mitogen-started protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway

Additionally, abnormal activation of LRRK2 downregulates SLC7A11 in microglia, impairing cystine import to inhibit GSH synthesis

The safest route is a medical clinic that prescribes compounded BPC-157 from a licensed US pharmacy and supervises the protocol

The committee's review was limited to specific nominated indications, but compounding pharmacies, if permitted to produce these substances, could legally dispense them for any condition a physician prescribes