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One major risk factor is obesity, which puts extra stress on joints like the knees and hips

If you have suffered from diabetic retinopathy or kidney problems, make this known as the condition could worsen with the drug

In human studies, GLP-1 receptor agonists may slightly increase bone formation markers (eg, osteocalcin, bone alkaline phosphatase) and acutely reduce bone resorption markers, but these effects are modest and inconsistent

Jul 16 2021;10(14)doi:10.3390/jcm10143144

In a 2006 study, an "anti-fat-burning" property emerges for carnitine by having a role in suppressing the gene involved in adipogenesis (increase in adipose tissue cells)