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This can lead to leaky gut, a condition that worsens digestion and nutrient absorption, including B12

Mitochondrial dysfunction that occurs in T2DM is inseparable from the glycolytic pathway, presumably it involves increased ROS production and energy expenditure (Qi et al., 2017)

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Due to CR-induced immune system depletion and mutagenesis/genotoxic events (leading to occurrence and accumulation of a driver mutation and genome instability), the risks of oncogene activation and tumor suppressor depletion required for conversion to tumorinitiating cells over long periods could increase (60)

Possemato E, La Barbera L, Nobili A et al (2023) The role of dopamine in NLRP3 inflammasome inhibition: implications for neurodegenerative diseases