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The number needed to treat for a two-level decrease in World Health Organization risk drinking level was 4.3

Hydroxyzine (prescribed for anxiety, urticaria, or pruritus) and mizolastine carry a recognised risk of QT prolongation, as highlighted in a 2015 MHRA Drug Safety Update on hydroxyzine

One monkey from the AMG 133 0.25 mg kg 1 group and two monkeys from the AMG 133 0.75 mg kg 1 group were excluded from the study/data analysis due to loss of exposure (antidrug antibody-mediated clearance)

The study was designed to evaluate weekly berobenatide and included a 28-week primary analysis and a 32-week exploratory extension to investigate higher weekly doses (1.6 mg, 2.4 mg) and less frequent dosing (every other week and monthly [2.4 mg, 3.2 mg, 4.8 mg])

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