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The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters

The lack of neuron damage in our study may also be due to the white matter's higher vulnerability compared to grey matter and the ongoing maturation of oligodendrocytes in 7-day-old mice 51

Overall, this research provides important insights into the interactions between antimalarial agents and Pf GR and encourages further exploration of its role in the mechanisms of action of antimalarials, including dual drugs, to enhance antiparasitic efficacy