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Exendin-4, the peptide isolated from Gila monster venomous saliva, became the foundation for exenatide, the first GLP-1 receptor agonist approved by the FDA in 2005 under the brand name Byetta

Hence, there was a suspicion of exendin-4's involvement in the inflammatory process and, indirectly and directly, in atherosclerosis development, which was investigated and then validated

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Sheu T, Vock DM, Mohamed AS, Gross N, Mulcahy C, Zafereo ME , Gunn GB, Garden AS, Sevak P, Phan J, Lewin JS, Frank SJ, Beadle BM, Morrison WH, Lai SY, Hutcheson K, Marai GE, Canahuate GM, Kies M, El-Naggar A, Weber RS, Rosenthal DI, Fuller CD