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A 2013 review in Aging Cell showed that declining systemic IGF-1 correlates with reduced dermal collagen density and skin elasticity in adults over 60

59 : 521528 Brown SL, Salive ME, Harris TB, Simonsick EM, Guralnik JM, Kohout FJ

Acknowledgements The authors offer sincere gratitude to the Head of the Department of Pharmaceutical Sciences, Dibrugarh University for providing the necessary facilities