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The majority of patients were White (85%) and 54% were male

The theoretical appeal might lie in combining distinct metabolic pathways to achieve enhanced effects

In the double-blinded Metformin to Augment Strength Training Effective Response in Seniors (MASTERS) trial (203), metformin, despite an increase in AMPK signaling, blunted the exercise-induced hypertrophic response in skeletal muscle in healthy men and women over the age of 65 who took part in a supervised progressive resistance exercise training program over 14 weeks following a 2 week metformin treatment (1700 mg/day, or placebo) (203)

Kelly AS, Auerbach P, Barrientos-Prez M, et al

Singly housed male C57BL/6JRj mice were fed a 60 kcal% fat diet (Research Diets, D12492) for 16 weeks