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Specifically, expression of the kidney injury molecule-1 (KIM-1) was quantified, and it was found that patients who died from APAP-associated acute liver failure or who required liver transplant had significantly higher KIM-1 values on day 1 of presentation, as compared to those who spontaneously survived

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Rapamycin was administered to dogs at a dose of approximately 0.025 mg/kg, using 0.25 mg increments