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Weight loss appeared as a secondary benefit in clinical trials, and it wasn't until 2021 that the FDA approved semaglutide specifically for obesity, validating what researchers had observed for years in diabetes patients

muscle loss with InBody analysis

Bahrainwala has seen patients who lost substantial weight on GLP-1 therapy and needed their blood pressure medications reduced or stopped altogether

individual tolerability varies

Semaglutide GLP-1, initially developed for managing type 2 diabetes, has been FDA-approved since June 2021 for chronic weight management in adults with obesity or those who are overweight and have at least one weight-related condition such as hypertension, type 2 diabetes, or hyperlipidemia