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But these medications don't work for many patients who have kidney disease, stomach ulcers, or other health issues [2]

Dec 16 2021;doi:10.1093/humupd/dmab038

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What reaches circulation is highly variable

Synovial inflammation is closely associated with peripheral sensitization via nerve growth factor (NGF) signaling, and imaging studies reveal strong correlations between synovial thickening, effusion, and OA symptom severity (Panichi et al., 2024