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This includes Pyruvate dehydrogenase deficiency (PDHD), mitochondrial respiratory chain disorders and glucose transporter type 1 deficiency syndrome (GLUT1-DS) 126,127

This injection route bypasses first-pass liver metabolism, allowing smaller doses to produce equivalent effects compared to oral formulations

Once inside the brain, ALCAR supports mitochondrial function in neurons and contributes its acetyl group for acetylcholine synthesis

developed a personalized joint-on-a-chip platform that integrates human chondrocytes and FLS isolated from OA patients into a compartmentalized microfluidic device ( 7.4 Autologous vascular compartment: a challenge toward immunocompetent aOoC systems Significant progress has been made in developing sophisticated OoC platforms for joint pathology, yet a fundamental physiological component remains insufficiently represented: the vascular network