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Given that GLP-1 regulates satiety, energy expenditure, and metabolism via neuronal pathways that are independent of the hypothalamus, GLP-1RAs may open up new opportunities either in isolation or in combination with other drugs to treat HO

Yu, M., Wang, K., Liu, H

doi: 10.1159/000192434

The peptide activates extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation in a dose-dependent manner, leading to nuclear translocation and activation of transcription factors including c-Fos, c-Jun, and early growth response-1 (Egr-1) that drive expression of genes involved in cell growth, migration, and angiogenesis

Role of intestinal microbiota and metabolites on gut homeostasis and human diseases