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Science , Jan
Longer-term liraglutide administration at the highest dose approved for obesity increases reward-related orbitofrontal cortex activation in response to food cues: Implications for plateauing weight loss in response to anti-obesity therapies
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For once-weekly preparations such as semaglutide (Ozempic, Wegovy) and dulaglutide (Trulicity), the time of day is generally less critical because these long-acting formulations maintain steady drug levels throughout the week
76,81,96,97 The main factor contributing to the lack of greater investment in lixisenatide and other short-acting agents for MASLD may be their influence on metabolic function, including pharmacokinetic differences induced by a single-dose method and their effects on gastric emptying, 91 which could limit their effectiveness in improving glycolipid metabolism
