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The regain is associated with an increase in risk factors for cardiometabolic conditions like diabetes and heart disease

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Notably, brain IR is implicated in neurodegenerative processes by affecting amyloid-beta metabolism and tau phosphorylation, linking it to both cognitive decline and mood disorders [7, 8]

Verkhratsky, A

152 , 153 Genetically determined GSSG-R deficiency has been documented in three siblings who were offspring of a consanguineous marriage